Events
Past Event
BME Seminar Series: Dr. Ian Wong
McCormick - Biomedical Engineering Department (BME)
4:00 PM
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Tech L361, Technological Institute
Details
Beyond 2D: Collective Cell Migration and Topological Data Analysis
ABSTRACT:
Epithelial cell migration is shaped by extracellular matrix architecture during development and disease, but the extracellular matrix is also dynamically remodeled by epithelial cells. Here, I present recent results from my group on the so-called epithelial-mesenchymal transition, whereby cells weaken cell-cell adhesions and gain a pro-invasive phenotype. First, we analyze the disorganization and dissemination of multicellular clusters cultured in 3D matrix, which exhibit both collective and individual invasion phenotypes with spatially non-uniform traction signatures. Second, we elucidate how larger multicellular spheroids transition from coordinated circumferential orbiting towards radial matrix invasion. Finally, we describe the use of topological barcodes for machine learning of tissue architecture based on spatial connectivity (i.e. persistent homology). We envision new insights into the dynamic reciprocity that emerges between cells and their physical microenvironment via mechanobiology and AI / ML approaches.
BIO:
Ian Wong is Associate Professor of Engineering, and of Pathology / Laboratory Medicine at Brown University. He engineers new miniaturized technologies based on biomaterials and microfluidics to investigate cancer cell invasion, drug resistance, and heterogeneity. He is also interested in the unconventional fabrication of bio and nano materials using self-assembly and 3D printing. He did his graduate work on the directed self-assembly of biomolecular materials with Nick Melosh, receiving a Ph.D. in Materials Science and Engineering from Stanford University. His postdoctoral training was with Mehmet Toner and Daniel Irimia at the Center for Engineering in Medicine at Massachusetts General Hospital. He has been recognized with an NSF Graduate Research Fellowship, a Damon Runyon Cancer Research Fellowship, the Brown University Pierrepont Award for Outstanding Advising and the Fain Engineering Faculty Research Award.
Time
Thursday, November 21, 2024 at 4:00 PM - 5:00 PM
Location
Tech L361, Technological Institute Map
Contact
Calendar
McCormick - Biomedical Engineering Department (BME)
BME Seminar Series: Zotero Workshop
McCormick - Biomedical Engineering Department (BME)
4:00 PM
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Tech L361, Technological Institute
Details
In this session, BME grad students will receive a brief introduction to general library services and literature searching. After that, they will be introduced to Zotero, a reference management tool. Zotero can help researchers collect, organize, annotate, share, and cite research. Using a citation management tool saves researchers hours of time and lots of frustration.
**Participants are encouraged to bring a laptop so they can start using Zotero during the session.
Becca Greenstein (Associate Librarian)
rgreenst@northwestern.edu
Time
Thursday, January 23, 2025 at 4:00 PM - 5:00 PM
Location
Tech L361, Technological Institute Map
Contact
Calendar
McCormick - Biomedical Engineering Department (BME)
BME Seminar Series: Dr. Huiliang (Evan) Wang
McCormick - Biomedical Engineering Department (BME)
4:00 PM
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Tech L361, Technological Institute
Details
Coming Soon!
Time
Thursday, January 30, 2025 at 4:00 PM - 5:00 PM
Location
Tech L361, Technological Institute Map
Contact
Calendar
McCormick - Biomedical Engineering Department (BME)
The Monthly Seminar on Physical Genomics: Mechanisms of Chromosome Folding - Job Dekker, PhD
Center for Physical Genomics and Engineering (CPGE)
12:00 PM
Details
Abstract
Chromosomes are intricately folded to facilitate accurate gene expression, DNA replication, and chromosome compaction and segregation as cells divide. I will first briefly introduce the current understanding of how mammalian chromosomes fold, focusing on the two known mechanisms that are currently widely studied: spatial segregation of eu- and heterochromatin through biophysical phase separation, and chromatin loop formation through loop extrusion by molecular motors such as cohesin and condensin complexes. I will then focus on how activity and interplay among multiple loop extruding complexes fold chromosomes, using mitotic chromosome formation as example. Next, I will address the question how cell type-specific interphase chromosome folding is inherited through mitosis. I will present evidence that interphase chromosome conformation is specified by distinct folding programs inherited via mitotic chromosomes or through the cytoplasm.
About Job Dekker
Job Dekker received his undergraduate and graduate training at Utrecht University in The Netherlands. As a post-doctoral fellow in the laboratory of Nancy Kleckner at Harvard University, he developed chromosome conformation capture methodology. He is currently an Investigator of the Howard Hughes Medical Institute and Professor in the Department of Systems Biology at the University of Massachusetts Chan Medical School. His laboratory studies how genomes are folded in three dimensions. His work has led to insights into the formation of chromatin loops involved in long-range gene regulation, the organization of the interphase nucleus, the structure of metaphase chromosomes, and general folding principles of genomes. His group pioneered the use of genome folding data for genome assembly. His lab explores chromosome folding mechanisms in organisms with unusual genome organizations, such as dinoflagellates.
Sponsored by the Center for Physical Genomics and Engineering, the Cancer and Physical Sciences Program at the Robert H. Lurie Comprehensive Cancer Center, and NIH Grants T32GM142604 and U54CA268084
Time
Friday, January 31, 2025 at 12:00 PM - 1:00 PM
Contact
Calendar
Center for Physical Genomics and Engineering (CPGE)
BME Seminar Series: Dr. Anders Sejr Hansen
McCormick - Biomedical Engineering Department (BME)
4:00 PM
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Tech L361, Technological Institute
Details
Coming Soon!
Time
Thursday, March 6, 2025 at 4:00 PM - 5:00 PM
Location
Tech L361, Technological Institute Map
Contact
Calendar
McCormick - Biomedical Engineering Department (BME)
BME Seminar Series: Dr. Chi Zhang
McCormick - Biomedical Engineering Department (BME)
4:00 PM
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Tech L361, Technological Institute
Details
Coming Soon!
Time
Thursday, April 3, 2025 at 4:00 PM - 5:00 PM
Location
Tech L361, Technological Institute Map
Contact
Calendar
McCormick - Biomedical Engineering Department (BME)
BME Seminar Series: Dr. Ross Ethier
McCormick - Biomedical Engineering Department (BME)
4:00 PM
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Tech L361, Technological Institute
Details
Coming Soon!
Time
Thursday, April 17, 2025 at 4:00 PM - 5:00 PM
Location
Tech L361, Technological Institute Map
Contact
Calendar
McCormick - Biomedical Engineering Department (BME)
BME Seminar Series: Dr. Robert Rose
McCormick - Biomedical Engineering Department (BME)
4:00 PM
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Tech L361, Technological Institute
Details
Coming Soon!
Time
Thursday, May 1, 2025 at 4:00 PM - 5:00 PM
Location
Tech L361, Technological Institute Map
Contact
Calendar
McCormick - Biomedical Engineering Department (BME)
BME Seminar Series: Dr. Ji-Xin Cheng
McCormick - Biomedical Engineering Department (BME)
4:00 PM
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Tech L361, Technological Institute
Details
Coming Soon!
Time
Thursday, May 15, 2025 at 4:00 PM - 5:00 PM
Location
Tech L361, Technological Institute Map
Contact
Calendar
McCormick - Biomedical Engineering Department (BME)