Modeling Chromatin as an Active Polymer Melt

Michael Shelley, PhD - Lilian and George Lyttle Professor of Applied Mathematics, NYU

In this talk, Prof. Shelley will discuss a line of work wherein chromatin in the nucleus is treated as a polymer upon which work is being done by active nuclear processes. These models range from Zimm polymer models acted upon by stochastic force dipoles, to a passive chromatin polymer immersed in an active nucleoplasm, to a continuum model of intermixed and active hetero- and euchromatic phases. Each model teaches us something about how the nucleus organizes itself through processes such as compaction and transcription. Prof. Shelley will also discuss recent work on modeling nuclear envelope rupture and repair as a free-boundary problem.

About Michael Shelley

Dr. Michael J. Shelley is an applied mathematician who works on the modeling and simulation of complex systems arising in physics and biology. He is the Lyttle Professor of Applied Mathematics at the Courant Institute, co-founder of the Courant Institute's Applied Mathematics Lab, and is the Director of the Center for Computational Biology at the Flatiron Institute. He holds a B.A. in mathematics from the University of Colorado and a Ph.D. in applied mathematics from the University of Arizona. He was a postdoctoral researcher at Princeton University and a member of the mathematics faculty at the University of Chicago before joining NYU. Shelley has received the François Frenkiel Award from the American Physical Society and the Julian Cole Lectureship from the Society for Industrial and Applied Mathematics, and he is a Fellow of both societies. He is also a Fellow of the American Academy of Arts and Sciences and a member of the National Academy of Sciences.

Register Here: https://tinyurl.com/2rw8n7bt

Sponsored by the Center for Physical Genomics and Engineering, the Cancer and Physical Sciences Program at the Robert H. Lurie Comprehensive Cancer Center, and NIH Grants T32GM142604 and U54CA268084

Related Info

Register Now