Dr. Yogesh Goyal
Assistant Professor of Cell and Developmental Biology
Chemical and Biological Engineering & Biomedical Engineering (by courtesy)
“Individual cells within genetically homogenous populations can respond differently to inductive signals or cues and adopt distinct fates. We combine novel experimental, computational, and theoretical frameworks to monitor, perturb, model, and ultimately control single-cell variabilities and emergent fate choices in development and disease, including cancer and developmental disorders. Our lab's interdisciplinary research program welcomes artists, biologists, chemists, clinicians, computer scientists, engineers, mathematicians, and physicists to work together and provide unique insights into biological systems.”

Dr. Guillermo Ameer
Professor of Biomedical Engineering & Surgery
Director of Center for Advanced Regenerative Engineering (CARE)
“Our research team develops biomaterials and nanotechnology for regenerative engineering, tissue engineering, medical devices, drug delivery, and cell delivery applications. We pioneered the development of citrate-based antioxidant biomaterials referred to as polydiolcitrates. Our research can be classified into two areas: 1) citrate-based elastomers and composites thereof, and 2) citrate-based injectable biomaterials.”

Dr. Thomas Meade
Professor of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, & Radiology Director of the Center for Advanced Molecular Imaging
“The Meade Lab research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research.”

Dr. Milan Mrksich
Professor of Biomedical Engineering, Chemistry, Cell & Developmental Biology
“Mrksich group’s interests overlap chemistry, biology and engineering, with an emphasis on the design and synthesis of materials that are biologically active and in applications of the materials to relevant problems in the biological and medical sciences. Much of our work uses self-assembled monolayers of alkanethiolates on gold to prepare model surfaces that are structurally defined, yet that can have complex compositions and present the ligands in spatially-organized patterns. We pioneered the design of ‘dynamic substrates’ that present ligands whose activities can be switched on and off in response to electrical or optical signals, particularly for studies that address the responses of adherent cells to changes in the extracellular matrix. These mimics of the extracellular matrix have led the way to the discovery of novel ligands that mediate cell adhesion. We have also developed robust surface chemistries for preparing biochip arrays and that are compatible with new analytical methods for analyzing the arrays.”

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https://www.mccormick.northwestern.edu/biomedical/news-events/bme-seminar-series/

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Beyond 2D: Collective Cell Migration and Topological Data Analysis

ABSTRACT:

Epithelial cell migration is shaped by extracellular matrix architecture during development and disease, but the extracellular matrix is also dynamically remodeled by epithelial cells. Here, I present recent results from my group on the so-called epithelial-mesenchymal transition, whereby cells weaken cell-cell adhesions and gain a pro-invasive phenotype. First, we analyze the disorganization and dissemination of multicellular clusters cultured in 3D matrix, which exhibit both collective and individual invasion phenotypes with spatially non-uniform traction signatures. Second, we elucidate how larger multicellular spheroids transition from coordinated circumferential orbiting towards radial matrix invasion. Finally, we describe the use of topological barcodes for machine learning of tissue architecture based on spatial connectivity (i.e. persistent homology). We envision new insights into the dynamic reciprocity that emerges between cells and their physical microenvironment via mechanobiology and AI / ML approaches.

BIO:

Ian Wong is Associate Professor of Engineering, and of Pathology / Laboratory Medicine at Brown University. He engineers new miniaturized technologies based on biomaterials and microfluidics to investigate cancer cell invasion, drug resistance, and heterogeneity. He is also interested in the unconventional fabrication of bio and nano materials using self-assembly and 3D printing. He did his graduate work on the directed self-assembly of biomolecular materials with Nick Melosh, receiving a Ph.D. in Materials Science and Engineering from Stanford University. His postdoctoral training was with Mehmet Toner and Daniel Irimia at the Center for Engineering in Medicine at Massachusetts General Hospital. He has been recognized with an NSF Graduate Research Fellowship, a Damon Runyon Cancer Research Fellowship, the Brown University Pierrepont Award for Outstanding Advising and the Fain Engineering Faculty Research Award.

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Fall classes end

The ceremony will take place on Saturday, December 14 in Pick-Staiger Concert Hall, 50 Arts Circle Drive.

*No tickets required

Coming Soon!

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