Abstract

The Groth group explores how the mammalian genome in its structural and functional context of chromatin is copied to maintain cell identity and fate, which is fundamental to organismal development, cancer and aging. We have pioneered the study of chromatin replication and epigenome maintenance, identifying mechanisms that underpin epigenetic cell memory and cell fate decision in development and disease. We have developed a panel of tailored omics technologies to address epigenome replication and combine these with structural studies and functional analysis in mouse embryonic stem cells. With these tools and approaches, we and our collaborators have provided evidence that histone-based information is transmitted by the DNA replication machinery to daughter strands, directly coupling epigenetic and genetic inheritance. By disrupting these processes, we find that transmission of histones through replication and inheritance to daughter cells is required to maintain genome regulation and stem cell identity. Prof. Groth will discuss the latest insights into how histone recycling maintains chromatin structure and function in the face of DNA replication and transcription.

About Anja Groth, PhD, Program Director and Professor, Novo Nordisk Foundation Center for Protein Research (CPR), Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen, Copenhagen, Denmark

Prof. Anja Groth has pioneered a new research area exploring how the mammalian genome in its structural and functional context of chromatin is copied to maintain cell identity and fate, which is fundamental to organismal development, cancer and aging. As an internationally recognized leader in her field, she is advancing science through innovative interdisciplinary research and technology development. She is a role model for young scientists, an entrepreneur, and an advocate for women in scientific leadership. Her achievements have been made possible through a unique leadership style and her ability to foster a highly collaborative inclusive research environment and creative space crossing disciplines.

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